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Is expressed in several structures, including cardiovascular system; fin bud; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). Genome Resources. Alliance ; Gene:64617 ; VEGA:OTTDARG00000012039 PrimePCR™ PreAmp for SYBR® Green Assay: S1pr1, Mouse Reaction: 400 reactions Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. S1PR1 (sphingosine-1-phosphate receptor 1), also known as S1P1, EDG1 and CD363, is a 7-transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family. S1PR1 is highly expressed in endothelial cells and binds the ligand sphingosine-1-phosphate (S1P) with high affinity and high specificity. Plasmid S1PR1-Tango from Dr. Bryan Roth's lab contains the insert S1PR1 and is published in Nat Struct Mol Biol.

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S1PR1 Antibodies S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. The S1PR1 gene encodes a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). There are 5 known S1P receptors with distinct but overlapping regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems. My Genes Showing 25 of 4,725 Results for S1PR1 Search Time: 0 ms Showing 25 50 100 200 500 See All of 4,725 Results for S1PR1 Search Time: 0 ms strong support for a role for S1PR1 gene variants in asthma susceptibility and severity. In four-and-a-half LIM domain protein (FHL)2-deficient bone marrow-derived dendritic cells (BMDC), repression of S1PR1 is lost, leading to its overexpression.

S1PR1 has 4,557 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasets. PrimePCR™ PreAmp for SYBR® Green Assay: S1PR1, Human Reaction: 400 reactions Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. The S1PR1 gene encodes a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P).

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Diseases associated with S1PR1 include Autoimmune Encephalitis and Herpes Zoster Oticus. Among its related pathways are Signaling by GPCR and S1P3 pathway.

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strong support for a role for S1PR1 gene variants in asthma susceptibility and severity. In four-and-a-half LIM domain protein (FHL)2-deficient bone marrow-derived dendritic cells (BMDC), repression of S1PR1 is lost, leading to its overexpression. Signaling via S1PR1 is responsible for increased migratory phenotype of FHL2-deficient BMDCs. 2021-03-02 2008-09-02 G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G (i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. The S1PR1 gene encodes a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). There are 5 known S1P receptors with distinct but overlapping regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems.

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Originally thought as an intracellular second messenger, it was discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. Sphingosine-1-phosphate - Wikipedia The molecular biology of phospho-fingolimod is thought to lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1.
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CD363, D1S3362, edg-1, EDG1: Description. Sphingosine-1-phosphate receptor 1 (HGNC Symbol) Entrez gene summary.

Gene symbol and name Data Source Assertion derived from less info Orthologs 1; Homo sapiens (human): S1PR1 (sphingosine-1-phosphate receptor 1) HGNC: EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam: Mus musculus (house mouse): S1pr1 (sphingosine-1-phosphate receptor 1) HGNC S1PR1 is crucial for lymphocyte secondary lymphoid organ retention for both T lymphocytes and B lymphocytes.
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Comparison of healthy  Sphingosine-1-phosphate receptor 1 (S1PR1) was found as a new target gene of miR-. 155 by in vitro and in vivo studies; its expression was decreased in SLE  mice in which the Smad2 gene is conditionally deleted in ECs using. Tie2-Cre transgenic Mice deficient in the S1PR1 gene exhibited embry- onic hemorrhage  This Anti-Sphingosine 1-phosphate receptor 1 (S1P1) Antibody, clone 8B7.1 is validated for use in Western Blotting, IHC for the Entrez Gene Number. EDG1 is a member of the endothelial differentiation gene family. It is a high affinity G protein-coupled receptor for the bioactive lipid, Sphingosine-1- phosphate.